Depression, anxiety, trauma, therapy, psychiatry, and what we now know about caring for the mind.
The metabolic, inflammatory, and structural roots of mental illness — mitochondria, gut, sleep, hormones.
Browse this topic →Trauma, attachment, cognition, and what the clinical literature still calls the talking cure.
Browse this topic →Psilocybin, MDMA, ketamine, and the renewed clinical research into psychedelic-assisted therapy for depression, PTSD, addiction, and end-of-life distress.
Browse this topic →Physician and trauma researcher Gabor Maté argues that autoimmune disease is rarely a random biological misfortune — it is the body saying …
Exhibitionism is one of the most clinically misunderstood paraphilias — dismissed as perversion or reduced to legal category. The psycholog…
Depression, anxiety, bipolar disorder, schizophrenia, epilepsy, anorexia, OCD, and phobia — each has a physiological and metabolic origin. …
Depression is not a serotonin deficiency. It is a disease of the HPA axis, mitochondrial dysfunction, and neuroinflammation. Five people wh…
Anxiety disorders begin with a failure of inhibitory GABA tone over the amygdala. Five people — generalised anxiety, panic, social, health …
Bipolar disorder is, at its metabolic core, a disease of unstable brain energy production. Five people who stabilised their mood cycling th…
Schizophrenia involves two interacting neurochemical disruptions — mesolimbic dopamine excess and prefrontal NMDA hypofunction — both downs…
Epilepsy was the first neurological condition shown to respond to ketogenic therapy — a century of evidence. Five cases illustrating how ke…
Anorexia nervosa is not a choice — it is a disorder of the hypothalamic dopamine reward circuit in which restriction becomes neurologically…
OCD is a disease of metabolic hyperactivation in the cortico-striato-thalamo-cortical circuit. Five people whose intrusive thought loops qu…
Specific phobias persist because fear extinction — an active, energy-demanding process — fails when PFC metabolism is impaired. Five people…
PTSD is the condition that results when traumatic fear memories fail to be contextualised. Chronic cortisol shrinks the hippocampus; amygda…
ADHD is a disorder of the prefrontal cortex — specifically of the dopaminergic and noradrenergic supply that enables sustained attention an…
Alzheimer's disease is increasingly understood as type 3 diabetes — brain insulin resistance that starves neurons of glucose decades before…
Alcohol use disorder forms because ethanol hijacks the GABA and dopamine systems the brain depends on for calm and reward. When alcohol wit…
A significant subset of autism involves mitochondrial dysfunction and gut-brain axis disruption that drives neuroinflammation. Five people …
Depression is not a choice, a character flaw, or a failure of will — it is a biological disorder in which the brain's reward circuitry goes…
The feeling of inner emptiness — the sense that nothing quite fills you, that you are always reaching for something just out of reach — is …
Every child faces a version of the same impossible dilemma: be yourself, or be loved. When being authentic — expressing anger, fear, sadnes…